| The enigmatic effects of caffeine in cell cycle and cancer. | |
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MedLine Citation:
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PMID: 16709440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, much of the research data regarding caffeine's effects on cell cycle and proliferation seem ambiguous. One important factor may be that caffeine has been used experimentally in numerous cell types under a variety of conditions at concentrations ranging from micromolar to high millimolar. Physiologically, achieving experimental blood levels of caffeine would be extremely difficult without adverse side effects. Therefore, the relevance of experimental data obtained by using high concentrations of caffeine is not clear and may account for some of the discrepancies in the literature. This review attempts to reconcile data regarding the cellular effects of caffeine by examining reported effects on cell cycle, proliferation and apoptosis with careful attention to differences in experimental conditions and caffeine concentration utilized. |
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Authors:
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Ann M Bode; Zigang Dong |
Publication Detail:
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Type: Journal Article; Review Date: 2006-05-18 |
Journal Detail:
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Title: Cancer letters Volume: 247 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-20 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 26-39 Citation Subset: IM |
Affiliation:
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The Hormel Institute, University of Minnesota, Austin, MN 55912, USA. ambode@hi.umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Caffeine / administration & dosage, adverse effects, pharmacology* Cell Cycle / drug effects Cell Proliferation / drug effects Cells, Cultured DNA Damage Dose-Response Relationship, Drug Humans Neoplasms / metabolism, pathology* Research Design Tumor Suppressor Protein p53 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA027502-270022/CA/NCI NIH HHS; P01 CA088961-01A10003/CA/NCI NIH HHS; P01 CA088961-020003/CA/NCI NIH HHS; R01 CA081064-05/CA/NCI NIH HHS; R01 CA081064-06/CA/NCI NIH HHS; R01 CA081064-07/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53; 58-08-2/Caffeine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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