Document Detail

The enigma of syndrome X.
MedLine Citation:
PMID:  2691418     Owner:  NLM     Status:  MEDLINE    
Syndrome X is characterised by chest pain suggestive of angina pectoris, normal epicardial coronary arteries on coronary angiography, and an exercise test with the characteristics (ST depression on the electrocardiogram) usually interpreted as myocardial ischaemia. The literature is confused because the last requirement, namely a positive exercise test, is not always present in groups of patients studied by a variety of techniques. The prognosis of patients with syndrome X is good. The cause is not known although many authors have argued that myocardial ischaemia due to small vessel disease is present. Coronary angiography cannot detect abnormalities of vessels less than 400 microns in diameter whilst electron-microscopy and light histology of biopsies visualise vessels less than 150 microns in diameter. Vessels of intermediate size could be abnormal and the abnormality be undetected. In many patients ischaemia cannot be the cause because the coronary sinus oxygen saturation is normal during an atrial pacing test when the patient complains of chest pain and changes are present on the surface electrocardiogram. Syndrome X describes an inhomogeneous group of patients with symptoms due to differing pathologies.
P A Poole-Wilson; T Crake
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  8     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  423-32     Citation Subset:  IM    
National Heart and Lung Institute, London, United Kingdom.
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MeSH Terms
Angina Pectoris / diagnosis*
Coronary Angiography*
Coronary Disease / diagnosis
Exercise Test

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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