Document Detail


The enigma of CD57+CD28- T cell expansion--anergy or activation?
MedLine Citation:
PMID:  8603525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Expansion of a CD57+CD8+ T lymphocyte subset has been reported in HIV and human cytomegalovirus (HCMV) infection. Almost all of these T cells lack CD28 expression. While CD28- cells are often associated with anergy, some authors believe their expansion in HIV infection precipitates immunodeficiency. We studied 15 randomly chosen patients with immune activation and observed that CD57+CD28- T cell expansion may occur in various conditions and to the same degree as in HIV infection without resulting in immunodeficiency. Triple colour flow cytometry also revealed that the CD57 and CD28 antigens are coexpressed in only 3% of CD8+ T cells, irrespective of the underlying condition, so that almost all CD57+CD8+ cells are always CD28-. Analysis of Fas (CD95) expression with respect to CD28 expression on CD4+ and CD8+ T cells from 10 additional patients indicated no increased commitment to apoptosis in CD28- T cells. Semiquantitative polymerase chain reaction (PCR) comparing CD28+ and CD28-CD8+ T cells with respect to cytokine gene expression (tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), IL-1beta) in five renal transplant patients with expansion of the CD57+ subset detected no cytokine gene expression deficit in CD28- T cells. A direct association of increased proportions of CD57+CD28-CD8+ T cells with immunodeficiency/anergy is disputed.
Authors:
F Kern; S Ode-Hakim; K Vogt; C Hoflich; P Reinke; H D Volk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  104     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-05-15     Completed Date:  1996-05-15     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
Affiliation:
Institut für Medizinische Immunologie der Charité, Humboldt Universität zu Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD28 / metabolism
Antigens, CD57 / metabolism*
Antigens, CD95 / metabolism
Cell Differentiation
Cytokines / genetics
Flow Cytometry
Gene Expression
Humans
Lymphocyte Activation
RNA, Messenger / genetics
Receptors, Interleukin-2 / genetics
T-Lymphocyte Subsets / cytology*
Chemical
Reg. No./Substance:
0/Antigens, CD28; 0/Antigens, CD57; 0/Antigens, CD95; 0/Cytokines; 0/RNA, Messenger; 0/Receptors, Interleukin-2

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