Document Detail

The enhancement of pipemidic acid permeation into the pig urinary bladder wall.
MedLine Citation:
PMID:  12062499     Owner:  NLM     Status:  MEDLINE    
The influence of interactions between polycarbophil and calcium on a model drug permeation into the pig urinary bladder wall was investigated. Pipemidic acid was used as a model drug. One percent w/v polycarbophil dispersion significantly increases the permeation of pipemidic acid into the urinary bladder wall. The enhanced absorption of pipemidic acid caused by polycarbophil is significantly less pronounced in polycarbophil dispersions containing calcium. The enhancement of pipemidic acid permeation into the urinary bladder wall could be due to the opening of tight junctions, which causes higher paracellular permeability. In the case of polycarbophil dispersion with calcium some carboxylic groups of polymer are already occupied with calcium, present in the dispersions. As a consequence extracellular calcium binds to polycarbophil in lower extent if compared with polycarbophil dispersion without calcium and transport is increased to a lesser degree. We concluded that the mechanism of drug absorption enhancement caused by polycarbophil could be similar for urinary bladder as described in the literature for intestinal mucosa.
M Kerec; V Svigelj; M Bogataj; A Mrhar
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  240     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia.
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MeSH Terms
Acrylic Resins / chemistry*
Calcium / chemistry,  metabolism*
Models, Biological
Pipemidic Acid / pharmacokinetics*
Tight Junctions / metabolism
Urinary Bladder / metabolism*
Urothelium / cytology,  metabolism
Reg. No./Substance:
0/Acrylic Resins; 51940-44-4/Pipemidic Acid; 7440-70-2/Calcium; 9003-97-8/calcium polycarbophil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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