| The enhancement of pipemidic acid permeation into the pig urinary bladder wall. | |
| | |
MedLine Citation:
|
PMID: 12062499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of interactions between polycarbophil and calcium on a model drug permeation into the pig urinary bladder wall was investigated. Pipemidic acid was used as a model drug. One percent w/v polycarbophil dispersion significantly increases the permeation of pipemidic acid into the urinary bladder wall. The enhanced absorption of pipemidic acid caused by polycarbophil is significantly less pronounced in polycarbophil dispersions containing calcium. The enhancement of pipemidic acid permeation into the urinary bladder wall could be due to the opening of tight junctions, which causes higher paracellular permeability. In the case of polycarbophil dispersion with calcium some carboxylic groups of polymer are already occupied with calcium, present in the dispersions. As a consequence extracellular calcium binds to polycarbophil in lower extent if compared with polycarbophil dispersion without calcium and transport is increased to a lesser degree. We concluded that the mechanism of drug absorption enhancement caused by polycarbophil could be similar for urinary bladder as described in the literature for intestinal mucosa. |
| | |
Authors:
|
M Kerec; V Svigelj; M Bogataj; A Mrhar |
Related Documents
:
|
8833779 - Urinary homovanillic acid and vanillylmandelic acid in workers exposed to carbon disulf... 8482589 - Determination of urinary alkoxyacetic acids by a rapid and simple method for biological... 438729 - Age related reference values for urinary free amino acids: a simple method of evaluation. 9285379 - Intestinal permeability in cystic fibrosis in relation to genotype. 1269739 - Radiopaque contrast media. xxxiv - derivatives of omega-(3-amino-2,4,6-triiodophenoxy)a... 2709249 - Dietary origin of retained h+ in infants with acquired monosaccharide intolerance. 670179 - Stimulating effect of hydrocortisone on the catabolism of endogenous fatty acyl groups ... 21718939 - Fully automated one-pot radiosynthesis of o-(2-[(18)f]fluoroethyl)-l-tyrosine on the tr... 487319 - Regional distribution of amino acids in friedreich's ataxia brains. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: 240 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2002 Jun |
Date Detail:
|
Created Date: 2002-06-13 Completed Date: 2002-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 33-6 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrylic Resins
/
chemistry* Animals Calcium / chemistry, metabolism* Models, Biological Pipemidic Acid / pharmacokinetics* Swine Tight Junctions / metabolism Urinary Bladder / metabolism* Urothelium / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Acrylic Resins; 51940-44-4/Pipemidic Acid; 7440-70-2/Calcium; 9003-97-8/calcium polycarbophil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular-weight-dependent pharmacokinetics and cytotoxic properties of cisplatin complexes prepared...
Next Document: Non-linear mixed effects models for the evaluation of dissolution profiles.