Document Detail

The enduring legacy of sham-controlled trials of internal mammary artery ligation.
MedLine Citation:
PMID:  23217427     Owner:  NLM     Status:  MEDLINE    
In 1959 and 1960 the results of two randomized controlled trials demonstrated that bilateral internal mammary artery ligation was no better than a sham intervention in the treatment of angina. These landmark trials were the first to use blinded placebo controls to evaluate invasive procedures. Revisiting the story of internal mammary artery ligation offers valuable insights into the ethics of sham-controlled trials and the implications of the placebo effect for thinking about risk-benefit assessment of sham procedures.
Franklin G Miller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  55     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-02-05     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  AIM; IM    
Copyright Information:
Published by Elsevier Inc.
Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892–1156, USA.
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MeSH Terms
Angina Pectoris / surgery*
Controlled Clinical Trials as Topic*
Coronary Artery Bypass / methods*
Mammary Arteries / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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