Document Detail

Is a strategy based on routine endotracheal cultures the best way to prescribe antibiotics in ventilator-associated pneumonia?
MedLine Citation:
PMID:  23348886     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The objectives of this study were to evaluate if a strategy based on routine endotracheal aspirate (ETA) cultures is better than using the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) guidelines to prescribe antimicrobials in ventilator-associated pneumonia (VAP).
METHODS: This was a prospective, observational, cohort study conducted in a 15-bed ICU and comprising 283 patients who were mechanically ventilated for ≥48 h. Interventions included twice-weekly ETA; BAL culture was done if VAP was suspected. BAL (collected at the time of VAP) plus ETA cultures (collected≤7 days before VAP) (n=146 different pairs) were defined. We compared two models of 10 days of empirical antimicrobials (ETA-based vs ATS/IDSA guidelines-based strategies), analyzing their impact on appropriateness of therapy and total antimicrobial-days, using the BAL result as the standard for comparison.
RESULTS: Complete ETA and BAL culture concordance (identical pathogens or negative result) occurred in 52 pairs; discordance (false positive or false negative) in 67, and partial concordance in two. ETA predicted the etiology in 62.4% of all pairs, in 74.0% of pairs if ETA was performed≤2 days before BAL, and in 46.2% of pairs if ETA was performed 3 to 7 days before BAL (P=.016). Strategies based on the ATS/IDSA guidelines and on ETA results led to appropriate therapy in 97.9% and 77.4% of pairs, respectively (P<.001). The numbers of antimicrobial-days were 1,942 and 1,557 for therapies based on ATS/IDSA guidelines and ETA results, respectively (P<.001).
CONCLUSIONS: The ATS/IDSA guidelines-based approach was more accurate than the ETA-based strategy for prescribing appropriate, initial, empirical antibiotics in VAP, unless a sample was available≤2 days of the onset of VAP. The ETA-based strategy led to fewer days on prescribed antimicrobials.
Carlos M Luna; Sergio Sarquis; Michael S Niederman; Fernando A Sosa; Maria Otaola; Nicolas Bailleau; Carlos A Vay; Angela Famiglietti; Célica Irrazabal; Abelardo A Capdevila
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  144     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2013-09-30     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-71     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Biopsy, Needle
Bronchoalveolar Lavage
Cohort Studies
Culture Techniques / methods*
Diagnostic Tests, Routine / methods*
Intensive Care Units
Middle Aged
Pneumonia, Ventilator-Associated / diagnosis*,  drug therapy*,  mortality
Practice Guidelines as Topic*
Prospective Studies
Retrospective Studies
Sensitivity and Specificity
Survival Rate
Trachea / microbiology*,  pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Chest. 2014 Apr;145(4):925   [PMID:  24687718 ]
Chest. 2014 Apr;145(4):925-6   [PMID:  24687719 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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