Document Detail


The endothelium: physiological functions and role in microcirculatory failure during severe sepsis.
MedLine Citation:
PMID:  20443110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulant, antifibrinolytic and is characterized by alterations of vasomotor regulation. Most of these functions have been discovered using in vitro and animal models, but in vivo exploration of endothelium in patients remains difficult. New tools to analyze endothelial dysfunction at bedside have to be developed.
Authors:
H Ait-Oufella; E Maury; S Lehoux; B Guidet; G Offenstadt
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-05
Journal Detail:
Title:  Intensive care medicine     Volume:  36     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1286-98     Citation Subset:  IM    
Affiliation:
Inserm U970, PAris Research Cardiovascular Center, Paris, France. hafid.aitoufella@sat.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Blood Coagulation / immunology
Cytokines / metabolism
Endothelium / blood supply,  immunology,  physiopathology*
Fibrinolysis / immunology
Humans
Leukocytes / immunology,  metabolism
Microcirculation / immunology*,  physiology
Sepsis / blood,  physiopathology*
Vasomotor System / immunology
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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