Document Detail

The endothelium in acute lung injury/acute respiratory distress syndrome.
MedLine Citation:
PMID:  18195622     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Since pulmonary edema from increased endothelial permeability is the hallmark of acute lung injury, a frequently encountered entity in critical care medicine, the study of endothelial responses in this setting is crucial to the development of effective endothelial-targeted treatments. RECENT FINDINGS: From the enormous amount of research in the field of endothelial pathophysiology, we have focused on work delineating endothelial alterations elicited by noxious stimuli implicated in acute lung injury. The bulk of the material covered deals with molecular and cellular aspects of the pathogenesis, reflecting current trends in the published literature. We initially discuss pathways of endothelial dysfunction in acute lung injury and then cover the mechanisms of endothelial protection. Several experimental treatments in animal models are presented, which aid in the understanding of the disease pathogenesis and provide evidence for potentially useful therapies. SUMMARY: Mechanistic studies have delivered several interventions, which are effective in preventing and treating experimental acute lung injury and have thus provided objectives for translational studies. Some of these modalities may evolve into clinically useful tools in the treatment of this devastating illness.
Nikolaos A Maniatis; Stylianos E Orfanos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in critical care     Volume:  14     ISSN:  1070-5295     ISO Abbreviation:  Curr Opin Crit Care     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504454     Medline TA:  Curr Opin Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-30     Citation Subset:  IM    
M. Simou Laboratory, University of Athens Medical School, Athens, Greece.
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MeSH Terms
Angiopoietins / metabolism
Cytoskeleton / metabolism,  ultrastructure
Endothelium, Vascular / pathology,  physiopathology*
Pulmonary Edema / pathology,  physiopathology,  prevention & control
Reactive Nitrogen Species / metabolism
Reactive Oxygen Species / metabolism
Renin-Angiotensin System / physiology
Respiratory Distress Syndrome, Adult / pathology,  physiopathology*,  prevention & control
Signal Transduction
Reg. No./Substance:
0/Angiopoietins; 0/Reactive Nitrogen Species; 0/Reactive Oxygen Species

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