| The endothelium in acute lung injury/acute respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 18195622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Since pulmonary edema from increased endothelial permeability is the hallmark of acute lung injury, a frequently encountered entity in critical care medicine, the study of endothelial responses in this setting is crucial to the development of effective endothelial-targeted treatments. RECENT FINDINGS: From the enormous amount of research in the field of endothelial pathophysiology, we have focused on work delineating endothelial alterations elicited by noxious stimuli implicated in acute lung injury. The bulk of the material covered deals with molecular and cellular aspects of the pathogenesis, reflecting current trends in the published literature. We initially discuss pathways of endothelial dysfunction in acute lung injury and then cover the mechanisms of endothelial protection. Several experimental treatments in animal models are presented, which aid in the understanding of the disease pathogenesis and provide evidence for potentially useful therapies. SUMMARY: Mechanistic studies have delivered several interventions, which are effective in preventing and treating experimental acute lung injury and have thus provided objectives for translational studies. Some of these modalities may evolve into clinically useful tools in the treatment of this devastating illness. |
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Authors:
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Nikolaos A Maniatis; Stylianos E Orfanos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in critical care Volume: 14 ISSN: 1070-5295 ISO Abbreviation: Curr Opin Crit Care Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504454 Medline TA: Curr Opin Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 22-30 Citation Subset: IM |
Affiliation:
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M. Simou Laboratory, University of Athens Medical School, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiopoietins
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metabolism Animals Cytoskeleton / metabolism, ultrastructure Endothelium, Vascular / pathology, physiopathology* Humans Pulmonary Edema / pathology, physiopathology, prevention & control Reactive Nitrogen Species / metabolism Reactive Oxygen Species / metabolism Renin-Angiotensin System / physiology Respiratory Distress Syndrome, Adult / pathology, physiopathology*, prevention & control Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Angiopoietins; 0/Reactive Nitrogen Species; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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