| The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure. | |
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MedLine Citation:
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PMID: 20299606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pathophysiological aldosterone (aldo)/mineralocorticoid receptor (MR) signaling has significant effects on the cardiovascular system, resulting in hypertension and cardiovascular remodeling; however, the specific contribution of the vascular MR to blood pressure regulation remains to be established. To address this question, we generated a mouse model with conditional overexpression of the MR in endothelial cells (MR-EC). In basal conditions, MR-EC mice developed moderate hypertension that could be reversed by canrenoate, a pharmacological MR antagonist. MR-EC mice presented increased contractile response of resistance arteries to vasoconstrictors (phenylephrine, thromboxane A(2) analog, angiotensin II, and endothelin 1) in the absence of vascular morphological alterations. The acute blood pressure response to angiotensin II or endothelin 1 infusion was increased in MR-EC mice compared with that in littermate controls. These observations demonstrate that enhanced MR activation in the endothelium generates an increase in blood pressure, independent of stimulation of renal tubular Na(+) transport by aldo/MR or direct activation of smooth muscle MR and establish one mechanism by which endothelial MR activation per se may contribute to impaired vascular reactivity. |
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Authors:
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Aurelie Nguyen Dinh Cat; Violaine Griol-Charhbili; Laurent Loufrani; Carlos Labat; Laura Benjamin; Nicolette Farman; Patrick Lacolley; Daniel Henrion; Frederic Jaisser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-18 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 24 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-08-03 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 2454-63 Citation Subset: IM |
Affiliation:
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INSERM UMRS 872, Team 1, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology Animals Blood Pressure* Cells, Cultured Endothelial Cells Endothelin-1 / pharmacology Endothelium, Vascular / physiology* Humans Mesenteric Arteries Mice Mice, Transgenic Receptors, Mineralocorticoid / physiology* Vasoconstriction / physiology* Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Receptors, Mineralocorticoid; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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