| The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. | |
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MedLine Citation:
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PMID: 19347350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triglyceride-rich postprandial lipoproteins are known to activate endothelial cells in vitro, contributing to atherosclerosis. Endothelial microparticles (EMP) are membranous vesicles released into the circulation from vascular endothelial cells that permit cell activation to be monitored in vivo. The objective of the study was to examine changes in EMP following a high fat meal, consumed with and without prior exercise. Eight recreationally active young men underwent two oral fat tolerance tests following either 100 min exercise at 70% VO(2)peak (EX trial) or no exercise (CON trial) on the previous evening. Postprandial triglycerides were reduced (1.97 +/- 0.31 vs. 1.17 +/- 0.13 mmol L(-1), p < 0.05) and HDL-cholesterol (HDL-C) increased (1.20 +/- 0.07 vs. 1.30 +/- 0.08 mmol L(-1), p < 0.05) in the EX compared to CON trial. EMP (CD31+/42b-) increased postprandially (p < 0.05). However, counts were not different between trials (postprandial CON and EX trial counts x 10(3 )microL(-1), 3.10 +/- 0.14 vs. 3.26 +/- 0.37). There were no changes in sICAM-1 or sVCAM-1 postprandially and no differences between trials. Interleukin-6 (IL-6) and leukocytes increased postprandially (p < 0.05). IL-6 values were not different between trials. Leukocytes were higher at 0 h in the EX trial with CON and EX trial values similar at 6 h. EMP, but not sICAM-1 or sVCAM-1, increase in response to a high fat meal. However, EMP are not attenuated by acute exercise, despite a considerable reduction in postprandial lipemia and an increase in HDL-C. |
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Authors:
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Michael Harrison; Ronan P Murphy; Paul L O'Connor; Donal J O'Gorman; Noel McCaffrey; Philip M Cummins; Niall M Moyna |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-05 |
Journal Detail:
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Title: European journal of applied physiology Volume: 106 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-09 Completed Date: 2009-08-19 Revised Date: 2009-10-28 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 555-62 Citation Subset: IM |
Affiliation:
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Department of Health, Sport and Exercise Science, Waterford Institute of Technology, Waterford, Ireland. mharrison@wit.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Adhesion Molecules / blood* Cell-Derived Microparticles / metabolism* Cholesterol, HDL / blood* Dietary Fats / metabolism* Endothelium, Vascular / cytology, physiology* Humans Male Physical Exertion / physiology* Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Cholesterol, HDL; 0/Dietary Fats; 0/Triglycerides |
| Comments/Corrections | |
Comment In:
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Eur J Appl Physiol. 2009 Nov;107(5):621-2
[PMID:
19701768
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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