Document Detail

An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure.
MedLine Citation:
PMID:  3720837     Owner:  NLM     Status:  MEDLINE    
We report here that topical application of clonidine displacing substance (CDS), an endogenous brain extract, directly in the nucleus reticularis lateralis (NRL) region of anaesthetized cats regularly produced hypertension. CDS (5 units) increased the mean blood pressure by 40 +/- 8%. Pretreatment of anaesthetized rabbits with intracisternal CDS (500 units) shifted to the right the dose-response curve obtained with clonidine alone injected the same way. This brain extract might be considered as an endogenous antagonist for the hypotensive effects of clonidine at least in the NRL region.
P Bousquet; J Feldman; D Atlas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  124     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Clonidine / antagonists & inhibitors*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Reg. No./Substance:

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