| An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure. | |
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MedLine Citation:
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PMID: 3720837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report here that topical application of clonidine displacing substance (CDS), an endogenous brain extract, directly in the nucleus reticularis lateralis (NRL) region of anaesthetized cats regularly produced hypertension. CDS (5 units) increased the mean blood pressure by 40 +/- 8%. Pretreatment of anaesthetized rabbits with intracisternal CDS (500 units) shifted to the right the dose-response curve obtained with clonidine alone injected the same way. This brain extract might be considered as an endogenous antagonist for the hypotensive effects of clonidine at least in the NRL region. |
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Authors:
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P Bousquet; J Feldman; D Atlas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 124 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-08-15 Completed Date: 1986-08-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 167-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Cats Clonidine / antagonists & inhibitors* Dose-Response Relationship, Drug Female Heart Rate / drug effects Male Microinjections |
| Chemical | |
Reg. No./Substance:
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4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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