Document Detail


The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.
MedLine Citation:
PMID:  18854136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell movements underlying the morphogenesis of the embryonic endoderm, the tissue that will give rise to the respiratory and digestive tracts, are complex and not well understood. Using live imaging combined with genetic labeling, we investigated the cell behaviors and fate of the visceral endoderm during gut endoderm formation in the mouse gastrula. Contrary to the prevailing view, our data reveal no mass displacement of visceral endoderm to extraembryonic regions concomitant with the emergence of epiblast-derived definitive endoderm. Instead, we observed dispersal of the visceral endoderm epithelium and extensive mixing between cells of visceral endoderm and epiblast origin. Visceral endoderm cells remained associated with the epiblast and were incorporated into the early gut tube. Our findings suggest that the segregation of extraembryonic and embryonic tissues within the mammalian embryo is not as strict as believed and that a lineage previously defined as exclusively extraembryonic contributes cells to the embryo.
Authors:
Gloria S Kwon; Manuel Viotti; Anna-Katerina Hadjantonakis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental cell     Volume:  15     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2008-11-24     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage*
Embryo, Mammalian / cytology,  metabolism
Endoderm / cytology*,  metabolism*
Extraembryonic Membranes / cytology*,  metabolism*
Gastrointestinal Tract / embryology
Gastrula
Gene Expression Regulation, Developmental
Green Fluorescent Proteins / metabolism
Image Processing, Computer-Assisted
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Transgenic
Models, Biological
Morphogenesis
RNA, Messenger / metabolism
Respiratory System / embryology
Transgenes
Grant Support
ID/Acronym/Agency:
R01 HD052115/HD/NICHD NIH HHS; R01 HD052115-01A1/HD/NICHD NIH HHS; R01 HD052115-02/HD/NICHD NIH HHS; R01 HD052115-03/HD/NICHD NIH HHS; R01-HD052115/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections
Comment In:
Dev Cell. 2008 Oct;15(4):493-4   [PMID:  18854133 ]

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