| The endocrinology of parturition in the human. | |
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MedLine Citation:
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PMID: 2248599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current evidence suggests that oestrogens, progesterone, relaxin, the prostaglandins, and oxytocin are all hormones concerned to a major degree with the onset and maintenance of parturition. Oestrogens, relaxin, and the prostaglandins are particularly involved with cervical ripening, while prostaglandins, progesterone and oxytocin are more involved in regulating myometrial contractility. Catecholamines may also have some regulatory function in relation to uterine contractions. Progesterone dominance during pregnancy is associated with a firm closed cervix, few myometrial gap junctions, low calcium levels in the cells, and a quiescent myometrium. At term, a change in the oestrogen/progesterone balance favours cervical ripening and increased uterine activity. Of particular importance at the level of the muscle cell are changes in the number of oxytocin receptors; a complex interaction between cAMP and phosphoinositide metabolism governs the intracellular level of calcium, thus regulating contractile activity. |
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Authors:
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P J Steer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Baillière's clinical endocrinology and metabolism Volume: 4 ISSN: 0950-351X ISO Abbreviation: Baillieres Clin. Endocrinol. Metab. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1991-01-04 Completed Date: 1991-01-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8704785 Medline TA: Baillieres Clin Endocrinol Metab Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 333-49 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catecholamines
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physiology Estrogens / physiology Female Humans Labor, Obstetric / physiology* Oxytocin / physiology, therapeutic use Pregnancy Progestins / physiology Prostaglandins / physiology, therapeutic use Uterine Contraction / physiology Vasopressins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Estrogens; 0/Progestins; 0/Prostaglandins; 11000-17-2/Vasopressins; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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