Document Detail

The endocrinology of parturition in the human.
MedLine Citation:
PMID:  2248599     Owner:  NLM     Status:  MEDLINE    
Current evidence suggests that oestrogens, progesterone, relaxin, the prostaglandins, and oxytocin are all hormones concerned to a major degree with the onset and maintenance of parturition. Oestrogens, relaxin, and the prostaglandins are particularly involved with cervical ripening, while prostaglandins, progesterone and oxytocin are more involved in regulating myometrial contractility. Catecholamines may also have some regulatory function in relation to uterine contractions. Progesterone dominance during pregnancy is associated with a firm closed cervix, few myometrial gap junctions, low calcium levels in the cells, and a quiescent myometrium. At term, a change in the oestrogen/progesterone balance favours cervical ripening and increased uterine activity. Of particular importance at the level of the muscle cell are changes in the number of oxytocin receptors; a complex interaction between cAMP and phosphoinositide metabolism governs the intracellular level of calcium, thus regulating contractile activity.
P J Steer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical endocrinology and metabolism     Volume:  4     ISSN:  0950-351X     ISO Abbreviation:  Baillieres Clin. Endocrinol. Metab.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-01-04     Completed Date:  1991-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8704785     Medline TA:  Baillieres Clin Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  333-49     Citation Subset:  IM    
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MeSH Terms
Catecholamines / physiology
Estrogens / physiology
Labor, Obstetric / physiology*
Oxytocin / physiology,  therapeutic use
Progestins / physiology
Prostaglandins / physiology,  therapeutic use
Uterine Contraction / physiology
Vasopressins / physiology
Reg. No./Substance:
0/Catecholamines; 0/Estrogens; 0/Progestins; 0/Prostaglandins; 11000-17-2/Vasopressins; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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