Document Detail

The endocrinological basis of recurrent miscarriages.
MedLine Citation:
PMID:  15976551     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review discusses the endocrinological aspects of recurrent miscarriage based on the literature from January 2004 to January 2005, elaborating on the advances in the field and their impact on diagnosis and management. RECENT FINDINGS: Endometrial luteal phase defect is associated with recurrent miscarriage. Fifty years have passed since the diagnostic criteria for dating the endometrial biopsy was established by Noyes et al. This has been the gold standard and last year its accuracy and clinical utility were critically analysed. A Cochrane review has shown a small but statistically significant difference in the live birth rate in the subgroup of women in which progestogen was used to prevent recurrent miscarriage. Endocannabinoids and fatty acid amide hydrolase have been found to have a potential role in signalling for implantation and maintenance of pregnancy. SUMMARY: Abnormal secretory endometrial changes may adversely affect the early pregnancy outcome. Other dating techniques using biochemical and molecular markers of endometrial function may prove useful in predicting outcome. Use of progestogens with or without estrogens for prevention of recurrent miscarriage needs to be investigated further in larger randomized controlled trials. The role of endocannabinoids and agents modulating their receptors are potentially very exciting areas to be explored further.
Neelam Potdar; Justin C Konje
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  17     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2006-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  424-8     Citation Subset:  IM    
Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, UK.
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MeSH Terms
Abortion, Habitual / blood,  etiology,  metabolism*
Angiogenesis Inhibitors / physiology
Embryo Implantation / physiology
Endocannabinoids / physiology
Endometrium / physiology*
Insulin Resistance
Killer Cells, Natural / physiology
Luteal Phase
Polycystic Ovary Syndrome / metabolism
Progesterone / blood*
Receptors, FSH / physiology
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Endocannabinoids; 0/Receptors, FSH; 57-83-0/Progesterone

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