Document Detail

The endocannabinoid system.
MedLine Citation:
PMID:  17125448     Owner:  NLM     Status:  MEDLINE    
The endocannabinoid system is a complex physiologic system. One of the most important discoveries related to the endocannabinoid system is that cannabinoid-1 receptors are present throughout the body and that they are linked to obesity and cardiometabolic risk. Adipose tissue was historically thought to be an inert, passive storage vehicle. However, recent findings prove that adipose tissue is a complex endocrine organ that releases adipokines, which influence cardiometabolic risk factors. Elevated endocannabinoid system activity is associated with obesity and coupled with excessive food intake and fat accumulation. Strong evidence suggests that the endocannabinoid system affects the surrogate cardiometabolic end points that greatly influence morbidity and mortality.
Steven T Boyd
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  26     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218S-221S     Citation Subset:  IM    
Xavier University, Natchitoches, Louisiana 71457, USA.
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MeSH Terms
Endocannabinoids / metabolism*
Obesity / metabolism
Receptor, Cannabinoid, CB1 / metabolism*
Receptor, Cannabinoid, CB2 / metabolism*
Reg. No./Substance:
0/Endocannabinoids; 0/Receptor, Cannabinoid, CB1; 0/Receptor, Cannabinoid, CB2

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