Document Detail


The end-of-life hospital setting in patients with glioblastoma.
MedLine Citation:
PMID:  18370888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite aggressive treatment, outcome of patients with glioblastoma is poor. Several distinct clinical problems arise in the terminal stage of this disease. The purpose of this study was to evaluate the end-of-life phase in a hospital setting in patients with glioblastoma. Twenty-nine consecutive patients with glioblastoma, who died in our department, were included in this analysis regarding symptoms, medication, diagnostics, and interventional procedures. The patients were comparable with respect to age, gender, and overall survival with data from the literature. Relevant clinical symptoms, medications, diagnostics, well as interventional procedures increased continuously toward end of life. Pain, epileptic seizures, and symptoms of brain edema were the most frequent clinical symptoms. According to this, most patients were on antiepileptic drugs (AED), steroids, and analgesics. In the last phase, symptoms from brain edema, fever, decrease of vigilance, dysphagia, and pneumonia were the prominent clinical features. Our study demonstrates that the end of life in patients with glioblastoma has several periods with different clinical aspects with respect to symptoms and treatment.
Authors:
Stefan Oberndorfer; Elisabeth Lindeck-Pozza; Heinz Lahrmann; Walter Struhal; Peter Hitzenberger; Wolfgang Grisold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of palliative medicine     Volume:  11     ISSN:  1096-6218     ISO Abbreviation:  J Palliat Med     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808462     Medline TA:  J Palliat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Affiliation:
Ludwig Boltzmann Institute for Neurooncology, Department of Neurology, KFJ-Hospital-SMZ-SUD, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Austria / epidemiology
Female
Glioblastoma / drug therapy,  physiopathology*,  radiotherapy
Hospitals*
Humans
Inpatients*
Male
Medical Audit
Middle Aged
Palliative Care
Retrospective Studies
Terminal Care* / methods
Terminally Ill*

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