| The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods: a food effect study. | |
| | |
MedLine Citation:
|
PMID: 21945866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The lipid emulsion Fabuless (Olibra) has been shown in some studies to decrease short/medium term energy intake (EI) and prevent weight regain. The purported mechanism is the ileal brake. Whether Fabuless is efficacious under a range of dietary conditions is unknown since studies have administered the emulsion within a fermented, semi-liquid dairy yoghurt, and outcomes have been inconsistent. To determine whether Fabuless suppresses post-ingestive satiety and short-term food intake under a range of dietary conditions and forms we administered the emulsion co-presented with 185 mL water, stirred into a semi-liquid dairy yoghurt, and co-presented with a solid food breakfast muffin. This was a cross-over study in 18 lean men randomised to 6 treatments: (i) lipid emulsion, LE (15 g Fabuless, containing 4.2g lipid, 0.2 MJ)+water, (ii) lipid control, LC (15 g non-emulsified lipid/water, containing 4.2g lipid, 0.2 MJ)+water, (iii) lipid emulsion+yoghurt, LE+Y (1.2 MJ), (iv) lipid control+yoghurt, LC+Y (1.2 MJ), (v) lipid emulsion+muffin, LE+M (1.2 MJ), (vi) lipid control+muffin, LC+M (1.2 MJ), each given as a test breakfast at 8.30 am. Participants rated postprandial appetite sensations using visual analogue scales (VAS), and ad libitum energy intake was measured at a lunch meal 3.5h later. The lipid emulsion increased fullness compared with an energy-matched lipid control but only when administered within the semi-liquid fermented yoghurt (P<0.05). There were no effects on satiety ratings when co-presented with water or with the solid food muffin. Energy and macronutrient intake were not significantly decreased by any of the emulsion treatments. We conclude that effects are small, the format in which lipid emulsions are consumed influences postprandial satiety, and there is no evidence that this emulsion alters eating behaviour at the subsequent meal. |
| | |
Authors:
|
Y-K Chan; C M Strik; S C Budgett; A-T McGill; J Proctor; S D Poppitt |
Related Documents
:
|
16860326 - Sugar questing mosquitoes in arid areas gather on scarce blossoms that can be used for ... 18343976 - A floral-derived compound attractive to the tephritid fruit fly parasitoid diachasmimor... 23618636 - Availability of limited service food outlets surrounding schools in british columbia. 11376456 - Lepidopteran peritrophic membranes and effects of dietary wheat germ agglutinin on thei... 20575536 - Trophodynamics of hexabromocyclododecanes and several other non-pbde brominated flame r... 18340476 - Effect of nutrition on toxicity of contaminants to the epibenthic amphipod melita plumu... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-09-17 |
Journal Detail:
|
Title: Physiology & behavior Volume: 105 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2011-12-14 Completed Date: 2012-04-16 Revised Date: 2012-06-13 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 742-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Human Nutrition Unit, University of Auckland, Auckland, New Zealand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analysis of Variance Appetite / drug effects* Cross-Over Studies Dietary Fats / administration & dosage* Eating / drug effects* Emulsions Energy Intake / drug effects Feeding Behavior / drug effects* Food Preferences / drug effects Humans Lipids / administration & dosage* Male Middle Aged Pain Measurement Time Factors Yogurt* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Emulsions; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Disruption of urinary odor preference and lordosis behavior in female mice given lesions of the medi...
Next Document: Acquired differences in brain responses among monozygotic twins discordant for restrained eating.