| The emerging roles of prohibitins in folliculogenesis. | |
| | |
MedLine Citation:
|
PMID: 22201905 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans. Prohibitins are ubiquitously expressed and present in multiple cellular compartments including the mitochondria, nucleus, and the plasma membrane, and shuttles between the mitochondria, cytosol and nucleus. Multiple functions have been attributed to the mitochondrial and nuclear prohibitins, including cellular differentiation, anti-proliferation, and morphogenesis. In the present review, we focus on the recent developments in prohibitins research related to folliculogenesis. Based on current research findings, the data suggest that these molecules play important roles in modulating specific responses of granulose cells to follicle stimulating hormone (FSH) by acting at multiple levels of the FSH signal transduction pathway. Understanding the molecular mechanisms by which the intracellular signaling pathways utilize prohibitins in governing folliculogenesis is likely to result in development of strategies to overcome fertility disorders and suppress ovarian cancer growth. |
| | |
Authors:
|
Indrajit Chowdhury; Minerva Garcia-Barrio; Djana Harp; Kelwyn Thomas; Roland Matthews; Winston E Thompson |
Related Documents
:
|
687875 - Prostaglandin production by macrophages and the effect of anti-inflammatory drugs. 22233885 - Proton production, regulation and pathophysiological roles in the mammalian brain. 3086225 - Development of antitumor activity in lps-stimulated mouse granuloma macrophages. regula... 9721925 - Macrophage inflammatory protein-1beta induces dexamethasone-unresponsive fever in rats. 21613335 - Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple scler... 12519385 - Nicotinamide is a potent inhibitor of proinflammatory cytokines. |
Publication Detail:
|
Type: Journal Article Date: 2012-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience (Elite edition) Volume: 4 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
|
Languages: eng Pagination: 690-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin-D regulation of bone mineralization and remodelling during growth.
Next Document: Linking atherosclerosis to Alzheimer's disease: focus on biomarkers.