Document Detail

The emerging roles of placenta-specific microRNAs in regulating trophoblast proliferation during the first trimester.
MedLine Citation:
PMID:  23046105     Owner:  NLM     Status:  Publisher    
In the human placenta, eight 'placenta-specific' microRNAs (miRNAs) are exclusively expressed and are associated with high cloning frequencies. The expression of placenta-specific miRNAs is known to be involved in preeclampsia, but the understanding of these miRNAs is still limited. The goal of this study was to investigate the levels and localisations of eight placenta-specific miRNAs in placental villi with different proliferative abilities during the first trimester. Immunohistochemical analyses indicated that placental trophoblast proliferation ability was associated with the weight of villi in the same gestational week during the first trimester. Of the eight placenta-specific miRNAs, quantitative real-time RT-PCR demonstrated that the expression of miR-517b and miR-1283 was increased in the lightest villi and decreased in the heaviest one, the expression of miR-519a was increased in the heaviest villi and decreased in the lightest one. In situ hybridisation analysis showed that miR-517b and miR-519a were located primarily in the trophoblast layer, while miR-1283 were expressed not only in the villous trophoblasts but also in some villous stroma cells. These findings suggest that miR-517b and miR-519a may play an important role in trophoblast proliferation during the first trimester.
Dan Wang; Weiwei Song; Quan Na
Related Documents :
24728945 - Effects of osteopontin on expression of il-6 and il-8 inflammatory factors in human kne...
24615935 - Ginsenosides may enhance the functionality of human embryonic stem cell-derived cardiom...
22389055 - Pioglitazone, pparγ agonist, attenuates experimental autoimmune neuritis.
18411415 - Placenta growth factor augments endothelin-1 and endothelin-b receptor expression via h...
16796685 - (p)ppgpp regulates type 1 fimbriation of escherichia coli by modulating the expression ...
17628895 - Histone acetylation and methylation in the signaling of steroid hormone receptors.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  -     ISSN:  1479-828X     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors ANZJOG © 2012 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Iterative refinement of a binding pocket model: active computational steering of lead optimization.
Next Document:  Who's Challenging Who? Changing attitudes towards those whose behaviour challenges.