| The emerging roles of melanopsin in behavioral adaptation to light. | |
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MedLine Citation:
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PMID: 20810319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adaptation of behavior and physiology to changes in the ambient light level is of crucial importance to life. These adaptations include the light modulation of neuroendocrine function and temporal alignment of physiology and behavior to the day:night cycle by the circadian clock. These non-image-forming (NIF) responses can function independent of rod and cone photoreceptors but depend on ocular light reception, suggesting the participation of novel photoreceptors in the eye. The discovery of melanopsin in intrinsically photosensitive retinal ganglion cells (ipRGCs) and genetic proof for its important role in major NIF responses have offered an exciting entry point to comprehend how mammals adapt to the light environment. Here, we review the recent advances in our understanding of the emerging roles of melanopsin and ipRGCs. These findings now offer new avenues to understand the role of ambient light in sleep, alertness, dependent physiologies and potential pharmacological intervention as well as lifestyle modifications to improve the quality of life. |
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Authors:
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Megumi Hatori; Satchidananda Panda |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-08-31 |
Journal Detail:
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Title: Trends in molecular medicine Volume: 16 ISSN: 1471-499X ISO Abbreviation: Trends Mol Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-03-17 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: England |
Other Details:
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Languages: eng Pagination: 435-46 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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radiation effects* Animals Behavior / radiation effects* Humans Light* Retinal Ganglion Cells / cytology, metabolism, radiation effects Rod Opsins / chemistry, genetics, metabolism* Vision, Ocular / radiation effects |
| Grant Support | |
ID/Acronym/Agency:
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EY16807/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Rod Opsins; 0/melanopsin |
| Comments/Corrections | |
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