Document Detail


The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease.
MedLine Citation:
PMID:  21885479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fatty acid translocase (FAT)/CD36 belongs to the class B scavenger receptor family. In addition to the known functions of CD36 in the uptake of oxidized low-density lipoprotein by macrophages and uptake of fatty acids by adipose tissues, skeletal muscle and heart, emerging evidence has pointed to an equally important function of CD36 in the uptake of fatty acids in the liver and the pathogenesis of fatty liver disease. Recent reports have also suggested CD36 as a shared transcriptional target of several ligand-sensing and lipogenic transcriptional factors, such as the aryl hydrocarbon receptor, and several nuclear hormone receptors, such as pregnane X receptor, liver X receptor and peroxisome proliferator activated receptor γ. Non-alcoholic fatty liver disease is common and medically significant, because it is closely related to metabolic syndrome and has a potential to progress into the more harmful non-alcoholic steatohepatitis. It is hoped that CD36 and their transcriptional regulators can represent novel therapeutic targets for the prevention and management of fatty liver disease.
Authors:
Jinhan He; Jung Hoon Lee; Maria Febbraio; Wen Xie
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-01
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  236     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-29     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1116-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD36 / metabolism,  physiology*
Fatty Liver / enzymology,  metabolism*
Gene Expression Regulation, Enzymologic / physiology
Humans
Liver / enzymology,  metabolism
Receptors, Aryl Hydrocarbon / metabolism,  physiology*
Receptors, Cytoplasmic and Nuclear / metabolism,  physiology
Grant Support
ID/Acronym/Agency:
DK083952/DK/NIDDK NIH HHS; ES014626/ES/NIEHS NIH HHS; R01 DK083952/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Receptors, Aryl Hydrocarbon; 0/Receptors, Cytoplasmic and Nuclear

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