| The emerging role of serine proteases in apoptosis. | |
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MedLine Citation:
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PMID: 17511651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unregulated apoptosis can be due to a disruption in the balance and control of both intra- and inter-cellular proteolytic activities leading to various disease states. Many proteases involved in apoptotic processes are yet to be identified; however, several are already well characterized. Caspases traditionally held the predominant role as prime mediators of execution. However, latterly, evidence has accumulated that non-caspases, including calpains, cathepsins, granzymes and the proteasome have roles in mediating and promoting cell death. Increasingly, research is implicating serine proteases within apoptotic processing, particularly in the generation of nuclear events such as condensation, fragmentation and DNA degradation observed in late-stage apoptosis. Serine proteases therefore are emerging as providing additional or alternative therapeutic targets. |
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Authors:
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K L Moffitt; S L Martin; B Walker |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 35 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 559-60 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, UK. kellylmoffitt@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Granzymes / metabolism Humans Mitochondrial Proteins / metabolism Serine Endopeptidases / metabolism* Serpins / metabolism Thrombin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Mitochondrial Proteins; 0/Serpins; EC 3.4.21.-/AP24 apoptotic protease; EC 3.4.21.-/Granzymes; EC 3.4.21.-/Omi serine protease; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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