| The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection. | |
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MedLine Citation:
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PMID: 22028331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LILRs represent a group of immunomodulatory molecules that regulate the functional properties of professional APCs and influence immune activation in a variety of disease contexts. Many members of the LILR family recognize peptide/MHC class I complexes as their physiological ligands, and increasing evidence suggests that such interactions are prominently influenced by polymorphisms in HLA class I alleles or sequence variations in the presented antigenic peptides. Emerging data show that LILRs are involved in multiple, different aspects of HIV-1 disease pathogenesis and may critically influence spontaneous HIV-1 disease progression. Here, we review recent progress in understanding the role of LILR during HIV-1 infection by focusing on the dynamic interplay between LILR and HLA class I molecules in determining HIV-1 disease progression, the effects of HIV-1 mutational escape on LILR-mediated immune recognition, the contribution of LILR to HIV-1-associated immune dysfunction, and the unique expression patterns of LILR on circulating myeloid DCs from elite controllers, a small subset of HIV-1-infected patients with natural control of HIV-1 replication. Obtaining a more complete understanding of LILR-mediated immune regulation during HIV-1 infection may ultimately allow for improved strategies to treat or prevent HIV-1-associated disease manifestations. |
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Authors:
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Mathias Lichterfeld; Xu G Yu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-10-25 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 91 ISSN: 1938-3673 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-04 Completed Date: 2012-02-27 Revised Date: 2012-05-10 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: IM |
Affiliation:
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Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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HIV Infections
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immunology*,
metabolism HIV-1 / immunology*, metabolism HLA Antigens / metabolism Humans Leukocytes / immunology*, metabolism, virology* Membrane Glycoproteins / physiology Receptors, HIV / metabolism, physiology* Receptors, Immunologic / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AI078799/AI/NIAID NIH HHS; AI089339/AI/NIAID NIH HHS; AI093203/AI/NIAID NIH HHS; R01 AI078799/AI/NIAID NIH HHS; R21 AI093203-01A1/AI/NIAID NIH HHS; R21 AI093203-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Membrane Glycoproteins; 0/Receptors, HIV; 0/Receptors, Immunologic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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