Document Detail


The emerging role of APC/CCdh1 in development.
MedLine Citation:
PMID:  21497201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/C(Cdh1) in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/C(Cdh1) in regulating crucial events during development.
Authors:
Dong Hu; Xinxian Qiao; George Wu; Yong Wan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-07
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  22     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-19     Completed Date:  2012-02-09     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  579-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anaphase / physiology*
Anaphase-Promoting Complex-Cyclosome
Animals
Cadherins / genetics,  metabolism*
Cdc20 Proteins
Cell Cycle Proteins / genetics,  metabolism
DNA Replication
G0 Phase / physiology*
G1 Phase / physiology*
Gene Expression Regulation, Developmental*
Genomic Instability
Hematopoiesis / physiology
Humans
Mice
Neurogenesis / physiology
Oogenesis / physiology
Protein Binding
Ubiquitin-Protein Ligase Complexes / genetics,  metabolism*
Ubiquitin-Protein Ligases / genetics,  metabolism*
Ubiquitination
Grant Support
ID/Acronym/Agency:
CA115943/CA/NCI NIH HHS; R01 CA115943/CA/NCI NIH HHS; R01 CA154695/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/CDH1 protein, human; 0/Cadherins; 0/Cdc20 Proteins; 0/Cell Cycle Proteins; 156288-95-8/CDC20 protein, human; EC 6.3.2.19/Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/Ubiquitin-Protein Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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