| The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. | |
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MedLine Citation:
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PMID: 19826416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation. Misregulation of Cdh1 thus has the potential to promote both cell-cycle re-entry and either perturbed differentiation or dedifferentiation. In addition, APC/C(Cdh1) is required to maintain genomic stability. As a result, loss of Cdh1 can contribute to tumorigenesis in the form of proliferation of poorly differentiated and genetically unstable cells. |
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Authors:
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R Wäsch; J A Robbins; F R Cross |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-10-12 |
Journal Detail:
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Title: Oncogene Volume: 29 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-07 Completed Date: 2010-02-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Department of Hematology and Oncology, University Medical Center, Freiburg, Germany. ralph.waesch@uniklinik-freiburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology Cell Cycle Proteins / metabolism, physiology* Cell Differentiation / physiology* Cell Proliferation Genomic Instability* Humans Models, Biological Neoplasms / genetics, pathology, physiopathology* Ubiquitin-Protein Ligase Complexes / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM047238-05A2/GM/NIGMS NIH HHS; R01 GM047238-06/GM/NIGMS NIH HHS; R01 GM047238-07/GM/NIGMS NIH HHS; R01 GM047238-08/GM/NIGMS NIH HHS; R01 GM047238-09/GM/NIGMS NIH HHS; R01 GM047238-10/GM/NIGMS NIH HHS; R01 GM047238-11/GM/NIGMS NIH HHS; R01 GM047238-12/GM/NIGMS NIH HHS; R01 GM047238-13/GM/NIGMS NIH HHS; R01 GM047238-14/GM/NIGMS NIH HHS; R01 GM047238-15/GM/NIGMS NIH HHS; R01 GM047238-16/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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