| The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly. | |
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MedLine Citation:
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PMID: 20685099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytomegalovirus infection is very common and leads to the generation of a very strong humoral and cellular immune response that is maintained for life and appears necessary to control viral replication. This leads to marked alterations in the composition of the immune cell repertoire and epidemiological evidence shows that this can be associated with increased levels of morbidity and mortality in the elderly. The immune response appears to be triggered by frequent episodes of subclinical viral reactivation and the predominant effect is of the accumulation of large numbers of cytotoxic cells. These observations suggest that mechanisms that could serve to control the expansion of this immune response could have significant potential in improving the health of elderly donors. |
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Authors:
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Paul Moss |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-08-03 |
Journal Detail:
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Title: Current opinion in immunology Volume: 22 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 529-34 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ltd. |
Affiliation:
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University of Birmingham, Edgbaston, Birmingham B15 2TA, United Kingdom. p.moss@bham.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / immunology* CD4-Positive T-Lymphocytes / immunology* Cytokines / metabolism Cytomegalovirus / physiology* Cytomegalovirus Infections / immunology*, therapy Humans Immunity, Cellular Immunity, Humoral |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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