Document Detail


The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer.
MedLine Citation:
PMID:  22373528     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. To design new therapeutic strategies, it is important to identify the signaling pathways and gene networks within this apparent complexity that are predominantly altered. The TGFβ signaling pathway and associated transcription network emerges as a central actor of pancreatic oncogenesis. Its tumor suppressor function in this tissue can be affected by several alterations.
Authors:
David J Birnbaum; Emilie Mamessier; Daniel Birnbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  683-6     Citation Subset:  IM    
Affiliation:
Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm; Institut Paoli-Calmettes; Marseille, France.
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