Document Detail

The emergence of patterned movement during late embryogenesis of Drosophila.
MedLine Citation:
PMID:  17577205     Owner:  NLM     Status:  MEDLINE    
Larval behavioral patterns arise in a gradual fashion during late embryogenesis as the innervation of the somatic musculature and connectivity within the central nervous system develops. In this paper, we describe in a quantitative manner the maturation of behavioral patterns. Early movements are locally restricted "twitches" of the body wall, involving single segments or parts of segments. These twitches occur at a low frequency and have low amplitude, reflecting weak muscle contractions. Towards later stages twitches increase in frequency and amplitude and become integrated into coordinated movements of multiple segments. Most noticeable among these is the peristaltic wave of longitudinal segmental contractions by which the larva moves forward or backward. Besides becoming more complex as development proceeds, embryonic movements also acquire a pronounced rhythm. Thus, late embryonic movements occur in bursts, with phases of frequent movement separated by phases of no movement at all; early movements show no such periodicity. These data will serve as a baseline for future studies that address the function of embryonic lethal genes controlling neuronal connectivity and larval behavior. We have analyzed behavioral abnormalities in two embryonic lethal mutations with severe neural defects, tailless (tll), which lacks the protocerebrum, and glial cells missing (gcm), in which glial cells are absent. Our results reveal prominent alterations in embryonic motility for both of these mutations, indicating that the protocerebrum and glial cells play a crucial role in the neural mechanism controlling larval movement in Drosophila.
Wayne Pereanu; Shana Spindler; Elisabeth Im; Natalie Buu; Volker Hartenstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Developmental neurobiology     Volume:  67     ISSN:  1932-8451     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1669-85     Citation Subset:  IM    
Copyright Information:
2007 Wiley Periodicals, Inc.
Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA.
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MeSH Terms
Behavior, Animal / physiology
Brain / embryology*
DNA-Binding Proteins / genetics
Drosophila / embryology*,  genetics
Drosophila Proteins / genetics
Embryo, Nonmammalian
Embryonic Development*
Larva / physiology
Movement / physiology*
Muscle Contraction / physiology
Muscle, Skeletal / embryology*,  innervation,  physiology
Neuroglia / metabolism
Repressor Proteins / genetics
Transcription Factors / genetics
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/GCM protein, Drosophila; 0/Repressor Proteins; 0/Tailless protein, Drosophila; 0/Transcription Factors

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