| The emergence of Ph-, trisomy -8+ cells in patients with chronic myeloid leukemia treated with imatinib mesylate. | |
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MedLine Citation:
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PMID: 12901975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe clinical and laboratory features of a cohort of patients with chronic myelogenous leukemia (CML) who developed Ph(-), trisomy 8(+) metaphases while on treatment with imatinib mesylate. PATIENTS AND METHODS: Conventional cytogenetics and triple-color interphase fluorescence in situ hybridization were used to identify 5 of 310 studied patients who, on follow-up analysis, had Ph(-), trisomy 8(+) cells while on therapy. RESULTS: None of the 5 patients had cytogenetic evidence of clonal evolution at the start of treatment with imatinib. All patients developed grade 3 or 4 neutropenia and thrombocytopenia during treatment. The emergence of Ph(-), trisomy 8(+) metaphases was seen at 3, 6, 13, 16, and 18 months from the start of treatment and was present at multiple time points. The maximum number of trisomy 8 metaphases ranged from 25 to 50%. Concomitantly, all patients had a profound suppression of Ph(+) cells (ranging from 0 to 65%) as well as the appearance of normal metaphases, ranging from 6 to 55%. None of the patients has shown clinical or hematologic signs of progression to a more advanced phase of CML. CONCLUSIONS: While on treatment with imatinib mesylate a small group (less than 5%) of patients with CML developed Ph(-) trisomy 8(+) clone associated with pancytopenia. None of the patients developed clinical or hematological signs of progression to a more advanced phase of CML. These observations suggest that identification of trisomy 8 cells may represent clonal Ph(-) cells that were uncovered by treatment with a selective and potent inhibitor of Ph(+) cells. |
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Authors:
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Eric Feldman; Vesna Najfeld; Michael Schuster; Gail Roboz; Amy Chadburn; Richard T Silver |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental hematology Volume: 31 ISSN: 0301-472X ISO Abbreviation: Exp. Hematol. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-06 Completed Date: 2003-09-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0402313 Medline TA: Exp Hematol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 702-7 Citation Subset: IM |
Affiliation:
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The Leukemia and Myeloproliferative Center, Weill Medical College of Cornell University, New York, NY, USA. ejf2001@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / adverse effects, therapeutic use* Chromosomes, Human, Pair 8 Clone Cells / pathology Enzyme Inhibitors / adverse effects, therapeutic use* Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy, genetics, pathology* Male Middle Aged Pancytopenia / chemically induced Philadelphia Chromosome Piperazines / adverse effects, therapeutic use* Pyrimidines / adverse effects, therapeutic use* Trisomy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib |
| Comments/Corrections | |
Comment In:
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Exp Hematol. 2005 Feb;33(2):151
[PMID:
15676207
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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