Document Detail


The embryonic mouse gut tube as a model for analysis of epithelial polarity.
MedLine Citation:
PMID:  22218905     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Recent accumulating data indicate links between planer cell polarity (PCP) and apicobasal (AB) polarity in epithelial cells. PCP regulatory genes have been shown to be involved in the establishment of AB polarity in addition to regulating PCP. We have shown that the gut tube of the mouse embryo is a unique model system for the analysis of epithelial polarities, e.g., oriented cell division and AB polarity, with respect to the PCP pathway. The regulation of epithelial polarity by the PCP pathway might play an essential role in organ morphogenesis relating to physiological function.
Authors:
Makoto Matsuyama; Akihiko Shimono
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  839     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
Affiliation:
Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.
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