Document Detail

An embryonal carcinoma multiple phenotype locus maps to the proximal position of the mouse X chromosome.
MedLine Citation:
PMID:  10767360     Owner:  NLM     Status:  MEDLINE    
A mutant embryonal carcinoma cell line, NR1-6, was established subsequent to retroviral insertion. The insertion was shown to be causative for a number of aberrant properties associated with the mutant cells. Analysis of >17 kb of the insertion site flanking region failed to reveal any homology between this locus and any reported sequence with the exception of one EST of unknown function and a few repetitive elements including B1 element and a CA dinucleotide repeat. CA repeats occur commonly in the mouse genome and usually show size variation. In this study, we mapped this multiphenotype locus using CA repeat polymorphism and Jackson Laboratory's interspecific backcross panels. The locus maps to the proximal end of the X chromosome between MGI offsets 1.5 and 4.5 and has been designated DXUalb1. There are several interesting candidate genes within this region. Analyses of their expression pattern may lead us to a better understanding of the molecular regulation of the variant mutant phenotypes.
L M Yu; F Zhang; P J McCormick
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Oncology reports     Volume:  7     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Center for the Study of Comparative Functional Genomics, University at Albany, SUNY, Albany, NY 12222, USA.
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MeSH Terms
Base Sequence
Carcinoma, Embryonal / genetics*
Chromosome Mapping*
Crosses, Genetic
DNA Transposable Elements
DNA, Neoplasm / chemistry,  genetics*
Dinucleotide Repeats
Genetic Markers
Mice, Inbred C57BL
Molecular Sequence Data
Tumor Cells, Cultured
X Chromosome*
Grant Support
Reg. No./Substance:
0/DNA Transposable Elements; 0/DNA, Neoplasm; 0/Genetic Markers

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