| The embryologic origin of ventral body wall defects. | |
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MedLine Citation:
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PMID: 20610194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventral body wall defects include ectopia cordis, bladder exstrophy, and the abdominal wall malformations gastroschisis and omphalocele. The etiology of ectopia cordis, gastroschisis, and bladder exstrophy is not known, but they may be linked to abnormalities in the lateral body wall folds responsible for closing the thoracic, abdominal, and pelvic portions of the ventral body wall. These folds form in the fourth week (postfertilization) of development as a combination of the parietal layer of lateral plate mesoderm and overlying ectoderm and must move ventrally to meet in the midline. There are differential rates of cell proliferation in the folds and asymmetries in their movement that may be involved in teratogenic effects of toxic factors. Also, the fusion process between the folds is complex, involving cell-to-cell adhesion, cell migration, and cell reorganization and all of these phenomena may be targets for disruption, leading to malformations. In this regard, closure of the ventral body wall is likened to neural tube closure and involves similar processes. It also encompasses a similar time frame during development, such that most neural tube and ventral body wall defects have their origins during the fourth week of development. Omphalocele is a separate entity whose etiology is known. This defect is attributed to a failure of gut loops to return to the body cavity after their normal physiological herniation into the umbilical cord from the 6th to 10th week of development. Thus, the origin of this defect is completely different from that of the ventral body wall malformations. |
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Authors:
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Thomas W Sadler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in pediatric surgery Volume: 19 ISSN: 1532-9453 ISO Abbreviation: Semin. Pediatr. Surg. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216162 Medline TA: Semin Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 209-14 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Division of Medical Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. tsadler@3riversdbs.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Wall
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abnormalities*,
embryology* Bladder Exstrophy / embryology, epidemiology, physiopathology Child Development / physiology Ectopia Cordis / embryology, epidemiology, physiopathology Female Follow-Up Studies Gastroschisis / embryology*, epidemiology, physiopathology Hernia, Umbilical / embryology, epidemiology, physiopathology Humans Incidence Infant, Newborn Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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