Document Detail

The elusive search for geographic clusters of systemic lupus erythematosus. Critical review.
MedLine Citation:
PMID:  7488276     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To ascertain whether there are any geographic clusters of systemic lupus erythematosus (SLE), and critically review 2 previous reports of these clusters. METHODS: A literature review of all epidemiologic surveys relevant to SLE published since 1966 was undertaken. This included a search of abstracts and reports, in addition to peer-reviewed publications. RESULTS: Two geographic clusters were identified in the literature. A report purporting that contaminated ground water in southwest Tucson, Arizona was associated with significantly increased symptoms of SLE was flawed since no patients were examined, discarded criteria were used, and incorrect definitions were employed by the nonrheumatologist authors. Another study, which identified a cluster in Nogales, Arizona, used generally valid methodology. However, the authors' conclusion that a 94/100,000 prevalence of SLE was evidence of an excessive increase in this 92% Hispanic/Native American community is not consistent with published surveys among Hispanic and Native American populations. CONCLUSION: No valid claims of SLE geographic clusters have been published.
D J Wallace; F P Quismorio
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  38     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1564-7     Citation Subset:  AIM; IM    
Cedars-Sinai Medical Center/UCLA School of Medicine 90048, USA.
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MeSH Terms
Arizona / epidemiology
Lupus Erythematosus, Systemic / epidemiology*
Comment In:
Arthritis Rheum. 1996 Nov;39(11):1935-7   [PMID:  8912522 ]

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