Document Detail


The elusive identity of T follicular helper cells.
MedLine Citation:
PMID:  20810318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secretion are exclusive properties of T cells that help B cells, and not all follicular T cells are B cell helpers. Indeed some follicular T cells appear to be suppressive. Furthermore, Tfh cells evolve during an immune response and B cells that have recently bound antigen, germinal center (GC) B cells and plasmablasts interact with phenotypically distinct Tfh cells. Here we propose that distinction between non-GC Tfh and GC Tfh cells might reconcile emerging controversies on Tfh cytokine secretion and the requirement of T-B cell interactions and SAP expression for Tfh formation.
Authors:
Di Yu; Carola G Vinuesa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-31
Journal Detail:
Title:  Trends in immunology     Volume:  31     ISSN:  1471-4981     ISO Abbreviation:  Trends Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Immunology, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / cytology,  immunology
Cell Differentiation
Germinal Center / immunology
Humans
Phenotype
T-Lymphocytes, Helper-Inducer / cytology,  immunology*

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