Document Detail

The elimination of alpha 2-macroglobulin complexes from the arthritic joint. An experimental study in dogs.
MedLine Citation:
PMID:  6186018     Owner:  NLM     Status:  MEDLINE    
The polyvalent protease inhibitor, alpha 2-macroglobulin, may counteract a protease-mediated rheumatoid joint destruction. The elimination of the complexed inhibitor from joints was analysed in inflamed and noninflamed conditions of the knee joints in dogs. The arthritis was immunologically induced. The fate of intra-articularly injected radioactive alpha 2-macroglobulin complexes was studied by external measurements, analyses of blood, lymph and urine, and by autoradiographic and immunohistologic methods. The results indicate that the elimination of complexes was accelerated by inflammation and joint movements with a half-life shorter than 2 hours in acute arthritis. In addition to absorption into the synovial membrane and degradation in macrophage-like cells, the process of clearance included elimination of complexes via the blood and the lymph capillaries of the joint and subsequent degradation in cells belonging to the reticuloendothelial system in the lymph nodes and the liver. The degradation products were excreted in increasing amounts in the urine. Referring to the earlier recognized high degree of saturation of synovial fluid alpha 2-macroglobulin in rheumatoid arthritis, the finding of a rapid articular clearance of alpha 2-macroglobulin complexes suggests a pronounced release of endoproteases under clinical conditions.
L Ekerot; K Ohlsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of plastic and reconstructive surgery     Volume:  16     ISSN:  0036-5556     ISO Abbreviation:  Scand J Plast Reconstr Surg     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121375     Medline TA:  Scand J Plast Reconstr Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
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MeSH Terms
Arthritis / metabolism*
Arthritis, Experimental / metabolism*
Knee Joint / metabolism
Lymph / analysis
Lymph Nodes / metabolism
Synovial Membrane / metabolism
Tissue Distribution
alpha-Macroglobulins / analysis,  metabolism*,  urine
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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