| The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma? | |
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MedLine Citation:
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PMID: 21082214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It seems quite clear that microRNAs play important roles in neuro-oncology, as they do across perhaps all areas in biology. With recent advances in detecting and quantifying microRNAs in tissue and serum, it appears increasingly likely that microRNAs will be clinically useful as biomarkers for brain tumors and other cancers. Applying microRNAs for treatment of brain tumors poses greater hurdles by far, however, and despite promising in vitro results this may never become a reality. This review fits recent advances into a framework for considering the potential of microRNAs for brain tumor therapy, considering the power of individual microRNAs, delivery issues, and indirect microRNA-based therapies. |
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Authors:
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Benjamin Purow |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-11-17 |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 103 ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-16 Completed Date: 2011-10-25 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: United States |
Other Details:
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Languages: eng Pagination: 429-36 Citation Subset: IM |
Affiliation:
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Neuro-Oncology Division, Neurology Department, University of Virginia, Charlottesville, VA, USA. bwp5g@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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genetics,
therapy* Glioblastoma / genetics, therapy* Humans MicroRNAs / genetics, metabolism, therapeutic use* Models, Molecular |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA136803/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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