Document Detail

The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?
MedLine Citation:
PMID:  21082214     Owner:  NLM     Status:  MEDLINE    
It seems quite clear that microRNAs play important roles in neuro-oncology, as they do across perhaps all areas in biology. With recent advances in detecting and quantifying microRNAs in tissue and serum, it appears increasingly likely that microRNAs will be clinically useful as biomarkers for brain tumors and other cancers. Applying microRNAs for treatment of brain tumors poses greater hurdles by far, however, and despite promising in vitro results this may never become a reality. This review fits recent advances into a framework for considering the potential of microRNAs for brain tumor therapy, considering the power of individual microRNAs, delivery issues, and indirect microRNA-based therapies.
Benjamin Purow
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-11-17
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  103     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-16     Completed Date:  2011-10-25     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
Neuro-Oncology Division, Neurology Department, University of Virginia, Charlottesville, VA, USA.
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MeSH Terms
Brain Neoplasms / genetics,  therapy*
Glioblastoma / genetics,  therapy*
MicroRNAs / genetics,  metabolism,  therapeutic use*
Models, Molecular
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