| An elemental diet controls inflammation in indomethacin-induced small bowel disease in rats: the role of low dietary fat and the elimination of dietary proteins. | |
| | |
MedLine Citation:
|
PMID: 16187203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Elemental diets (EDs) are effective in treating Crohn's disease. We hypothesize that low dietary fat and amino acids used as the sole nitrogen source are the major contributors for the success of EDs. We examined the influences of the addition of dietary fat and protein to an ED using an indomethacin-induced inflammation model in rat small intestine. In the ED-fed rats, the intestinal damage score was decreased compared with that in the standard chow group with decreasing intestinal permeability. By supplementing an ED with soybean oil (SO), intestinal permeability was increased to a level similar to that of the standard chow group. For this group, the intestinal damage score also increased compared with that of the ED group but did not reach the levels observed in the standard chow group. The addition of dietary proteins (using heat-denatured pancreatin) resulted in intestinal damage scores that were significantly higher than those of the ED+SO-fed group. The dietary protein increased the intestinal damage score. These results suggest that EDs control inflammation by decreasing intestinal permeability and the elimination of dietary proteins. |
| | |
Authors:
|
Hideki Suzuki; Nozomi Hanyou; Ichiro Sonaka; Hisanori Minami |
Related Documents
:
|
6263463 - Effect of diet on fecal excretion and gastrointestinal tract distribution of unmetaboli... 2043603 - Activities of enzymes of the pancreas, and the lumen and mucosa of the small intestine ... 8582863 - Immune response, glucose metabolism, and performance of stressed feeder calves fed inor... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 50 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-09-27 Completed Date: 2005-11-22 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 1951-8 Citation Subset: AIM; IM |
Affiliation:
|
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Kumamoto, Japan. hideki_suzuki@ajinomoto.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Crohn Disease / chemically induced, diet therapy*, pathology Dietary Proteins / pharmacokinetics, therapeutic use Disease Models, Animal Food, Formulated* Gastrointestinal Agents / pharmacokinetics, therapeutic use Indomethacin Intestine, Small / pathology Male Pancreatin / pharmacokinetics, therapeutic use Rats Rats, Sprague-Dawley Soybean Oil / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Proteins; 0/Gastrointestinal Agents; 53-86-1/Indomethacin; 8001-22-7/Soybean Oil; 8049-47-6/Pancreatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestina...
Next Document: Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.