| The electrophysiology of acute myocardial ischemia. | |
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MedLine Citation:
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PMID: 2581499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cellular events leading to clinical manifestations of acute (less than 30 minutes) ischemia are discussed, with emphasis on the role of early extracellular K+ accumulation and its effect on sodium current kinetics, which causes changes in excitability, conduction, and refractory periods. These are the cellular phenomena responsible for ST elevation, reentry, and enhanced automaticity, which characterize the early clinical events in ischemia. During this early period, ATP levels are normal and calcium metabolism appears normal. |
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Authors:
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H A Fozzard; J C Makielski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of medicine Volume: 36 ISSN: 0066-4219 ISO Abbreviation: Annu. Rev. Med. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-17 Completed Date: 1985-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985151R Medline TA: Annu Rev Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Acute Disease Calcium / metabolism Coronary Disease / physiopathology* Electrocardiography Heart / physiopathology* Humans Ion Channels / physiology Male Middle Aged Myocardial Contraction Myocardium / metabolism Potassium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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