Document Detail

The electrophysiology of acute myocardial ischemia.
MedLine Citation:
PMID:  2581499     Owner:  NLM     Status:  MEDLINE    
The cellular events leading to clinical manifestations of acute (less than 30 minutes) ischemia are discussed, with emphasis on the role of early extracellular K+ accumulation and its effect on sodium current kinetics, which causes changes in excitability, conduction, and refractory periods. These are the cellular phenomena responsible for ST elevation, reentry, and enhanced automaticity, which characterize the early clinical events in ischemia. During this early period, ATP levels are normal and calcium metabolism appears normal.
H A Fozzard; J C Makielski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  36     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Acute Disease
Calcium / metabolism
Coronary Disease / physiopathology*
Heart / physiopathology*
Ion Channels / physiology
Middle Aged
Myocardial Contraction
Myocardium / metabolism
Potassium / metabolism
Reg. No./Substance:
0/Ion Channels; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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