| The electrophysiological effects of lithium in the rat. | |
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MedLine Citation:
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PMID: 199555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of lithium on the tail nerve conduction velocity of the rat were studied. No effect of lithium on the conduction velocity was found, even at toxic serum lithium levels. No effect of lithium on repetitive stimulation of the distal forelimb flexor muscles was seen. The results suggest that electrophysiological measurements do not provide an effective means of titrating serum lithium levels in the rat. The results may have clinical signficance since they provide evidence against neuropathic or neuromuscular transmission defects as the cause of the transient weakness of some patients taking lithium. |
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Authors:
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J R Samples; M E Seybold |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International pharmacopsychiatry Volume: 12 ISSN: 0020-8272 ISO Abbreviation: Int Pharmacopsychiatry Publication Date: 1977 |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0135645 Medline TA: Int Pharmacopsychiatry Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / blood Lithium / pharmacology*, toxicity Magnesium / blood Male Neural Conduction / drug effects* Neuromuscular Junction / physiology* Rats Synaptic Transmission / drug effects* |
| Chemical | |
Reg. No./Substance:
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7439-93-2/Lithium; 7439-95-4/Magnesium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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