Document Detail

The electrophysiologic effects of quinidine in the transplanted human heart.
MedLine Citation:
PMID:  320227     Owner:  NLM     Status:  MEDLINE    
Using His bundle recording techniques, we examined direct and autonomically mediated conduction system effects of quinidine in five cardiac transplant recipients who have anatomically denervated hearts. We made control conduction interval and refractory period measurements, and then infused 10 mg/kg quinidine gluconate over a 20-min period. At 30 min, we determined the electrophysiologic changes induced by quinidine. Quinidine significantly increased the atrial-His (AH) interval (from 97+/-9 [SEM] to 108+/-7 ms, P less than 0.001), the His-ventricular (HV) inteval (from 43.9 +/- 1 to 52.8 +/- 3 ms, P less than 0.01), the donor heart sinus cycle length (from 599 +/- 38 to 630 +/- 56 ms, P less than 0.08), and the atrial effective refractory period (from 214 +/- 14 to 241 +/- 11 ms, P less than 0.01). Quinidine significantly decreased the innervated, remnant atrial sinus cycle length (from 847 +/- 104 to 660 +/- 96 ms, P less than 0.01) and the blood pressure. The mean plasma concentration of quinidine at the time that electrophysiologic measurements were repeated was 4.37 +/- 0.449 micrograms/ml. We conclude that quinidine's predominant sinus nodal and atrioventricular nodal effects in man are autonomically mediated and opposite to its direct actions upon these structures. On the other hand, quinidine's prevailing effect on atrial refractoriness and His-Purkinje conduction in man is direct.
J W Mason; R A Winkle; A K Rider; E B Stinson; D C Harrison
Related Documents :
1378157 - Effects of carvedilol on atrial natriuretic peptide, catecholamines, and hemodynamics i...
3149327 - Av nodal reentrant tachycardia with a bystander mahaim fiber.
630677 - Clinical electrophysiologic effects of tocainide.
3992057 - Chronotropic effects of the reversed carboxyl (rc) analogue of acetylcholine (beta-homo...
3112657 - The influence of dialysis fluid composition on dialysis tolerance.
9575947 - In vivo murine left ventricular pressure-volume relations by miniaturized conductance m...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  59     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Electrophysiology / economics
Heart Conduction System / drug effects*
Heart Transplantation*
Quinidine / blood,  pharmacology*
Sinoatrial Node / drug effects
Transplantation, Homologous
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients wi...
Next Document:  Role of in vitro and in vivo tests of hypersensitivity in beryllium workers.