Document Detail


An electrochemotherapy model for rat tongue carcinoma.
MedLine Citation:
PMID:  9707276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrochemotherapy (ECT) is a new technique that enhances the antitumor effect of various anticancer agents by delivering high-voltage electrical impulses to the tumor. A rat squamous cell carcinoma and a hepatocellular carcinoma were transplanted into the tongues of rats and subjected to a) high-voltage electrical impulses 30 min after the injection of bleomycin, b) bleomycin treatment alone, and c) electrical treatment alone. A non-treated control group was also included. Following ECT, the tongue tumors were no longer visible from the 3rd day after treatment and histological examination revealed complete regression, whereas tumors that received either high-voltage impulses alone or bleomycin alone showed no detectable changes. The healing process following ECT progressed smoothly, including that of the normal tissue within the electrical field that was seriously damaged. ECT was shown to be an efficient therapy for treating tumors of the tongue, and it is expected to be suitable for the treatment of human oral cancers as soon as problems related to ECT damage of normal tissue are overcome.
Authors:
H Hasegawa; M Kano; N Hoshi; K Watanabe; E Satoh; B Nakayama; T Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  27     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-14     Completed Date:  1998-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  D; IM    
Affiliation:
Department of Oral Surgery, Fukushima Medical College, Fukushima City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimetabolites, Antineoplastic / administration & dosage,  therapeutic use*
Bleomycin / administration & dosage,  therapeutic use*
Carcinoma, Hepatocellular / drug therapy*,  pathology,  therapy
Carcinoma, Squamous Cell / drug therapy*,  pathology,  therapy
Electric Stimulation Therapy
Electroporation
Epithelium / pathology
Humans
Iontophoresis / methods*
Necrosis
Neoplasm Transplantation
Rats
Rats, Inbred F344
Rats, Inbred Strains
Remission Induction
Tongue / pathology
Tongue Neoplasms / drug therapy*,  pathology,  therapy
Tumor Cells, Cultured
Wound Healing
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 11056-06-7/Bleomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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