Document Detail

The efflux of nor-epinephrine from platelets in essential hypertension.
MedLine Citation:
PMID:  1823895     Owner:  NLM     Status:  MEDLINE    
The precise role of sympathetic nervous system in initiation and/or maintenance of essential hypertension is unclear even today. Platelets have been used as a suitable model for studying neuronal turnover of biogenic amines. The present study comprised of hypertensive subjects (23) and normotensive controls (10). Hypertensive subjects exhibited significantly enhanced norepinephrine efflux from platelets at both 30 minutes and 60 minutes (p less than 0.001). The percent norepinephrine efflux from platelets correlated with diastolic (r = 0.66 and 0.76) and mean arterial blood pressure (r = 0.54 and 0.65) but not with systolic blood pressure. The norepinephrine efflux rate (K) similarly correlated with diastolic and mean arterial blood pressure in hypertensive subjects studied. From the above findings it appears that operative sympathetic nervous system activity is enhanced in essential hypertension. The enhanced efflux of norepinephrine from platelets may also indicate activated state of platelets in hypertension. Both could be important in genesis and complications of essential hypertension.
N Chandra; M Chandra; S N Pandeya; S Dhawan; D Soni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  43     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-10-08     Completed Date:  1992-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  461-3     Citation Subset:  IM    
Department of Medicine, King George's Medical College, Lucknow.
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MeSH Terms
Age Factors
Blood Platelets / secretion*
Blood Pressure / physiology
Hypertension / metabolism,  physiopathology*
Middle Aged
Norepinephrine / secretion*
Sympathetic Nervous System / physiopathology
Reg. No./Substance:

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