Document Detail

An efficient and practical synthesis of mandelic acid by combination of complex phase transfer catalyst and ultrasonic irradiation.
MedLine Citation:
PMID:  18424219     Owner:  NLM     Status:  MEDLINE    
Mandelic acid was synthesized from benzaldehyde with chloroform in a 81% yield at 60 degrees C for 2 h by using triethylbenzylammonium chloride (TEBA) and poly(ethylene glycol)-800 (PEG-800) as a complex phase transfer catalyst under ultrasonic irradiation. The main advantages of this present method are that the reaction time is much shorter and the yield is higher than those of the classical method. p-Methoxymandelic acid was also obtained in a 84% yield under the same reaction conditions.
Hui Xu; Yang Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-13
Journal Detail:
Title:  Ultrasonics sonochemistry     Volume:  15     ISSN:  1350-4177     ISO Abbreviation:  Ultrason Sonochem     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433356     Medline TA:  Ultrason Sonochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  930-2     Citation Subset:  IM    
Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China.
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MeSH Terms
Chloroform / chemistry
Indicators and Reagents
Mandelic Acids / chemical synthesis*,  radiation effects
Polyethylene Glycols / chemistry
Solvents / chemistry
Reg. No./Substance:
0/Indicators and Reagents; 0/Mandelic Acids; 0/Polyethylene Glycols; 0/Solvents; 67-66-3/Chloroform; 90-64-2/mandelic acid

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