| An efficient pH sensitive oral insulin delivery system enhanced by deoxycholic acid. | |
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MedLine Citation:
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PMID: 22195840 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A permeation enhancer, positively charged deoxycholyl-hyperbranched oligoethylenimine (DCO), was prepared and used to form complexes with negatively charged insulin based on electrostatic interaction. DCO/insulin complexes can be loaded into poly (l-glutamic acid) (PGA) microspheres by the oil-in-oil (O/O) emulsion and solvent evaporation technique. Because of the specific pH sensitive properties of PGA, these insulin encapsulated microspheres are stable in the stomach and disaggregate in the small intestine, and the bioavailability of oral insulin administration will be improved due to DCO's permeation enhancement function. |
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Authors:
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Li Zhao; Jianxun Ding; Pan He; Chunsheng Xiao; Zhaohui Tang; Xiuli Zhuang; Xuesi Chen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 152 Suppl 1 ISSN: 1873-4995 ISO Abbreviation: J Control Release Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: e184-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Graduate University of the Chinese Academy of Sciences, Beijing 100039, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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