Document Detail

The efficiency of first-trimester serum analytes and maternal characteristics in predicting fetal growth disorders.
MedLine Citation:
PMID:  19716535     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the association between first-trimester serum analytes, pregnancy-associated plasma protein A and free beta-human chorionic gonadotropin, and fetal growth disorders, and to determine whether a prediction model for these growth disorders can be developed. STUDY DESIGN: Retrospective cohort study of patients seen for first-trimester aneuploidy screening. Pregnancy-associated plasma protein A and free beta-human chorionic gonadotropin multiples of the median were evaluated for association with small- and large-for-gestational-age infants in combination with maternal characteristics. Univariate and backward stepwise logistic regression analyses were performed and the area under the receiver-operator curves used to determine the best prediction models. RESULTS: Neither pregnancy-associated plasma protein A nor free beta-human chorionic gonadotropin levels were associated with an increased risk of large-for-gestational-age infants. For small-for-gestational-age infants, the final model included black race, free beta-human chorionic gonadotropin multiples of the median >90th percentile, and pregnancy-associated plasma protein A multiples of the median <5th percentile as significant predictors (area under the curve = 0.58). CONCLUSION: Low pregnancy-associated plasma protein A and high free beta-human chorionic gonadotropin levels are associated with a small-for-gestational-age growth pattern; however, additional factors to improve the prediction model are needed.
Katherine R Goetzinger; Ashima Singla; Sabrina Gerkowicz; Jeffrey M Dicke; Diana L Gray; Anthony O Odibo
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Publication Detail:
Type:  Journal Article     Date:  2009-08-28
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  201     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-30     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412.e1-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Washington University, St. Louis, MO, USA.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Fetal Growth Retardation / blood*
Fetal Macrosomia / blood*
Gestational Age
Logistic Models
Predictive Value of Tests
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis*
ROC Curve
Retrospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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