| The efficacy and tolerability of an angiotensin II receptor blocker, telmisartan, in Thai patients with mild to moderate essential hypertension. | |
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MedLine Citation:
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PMID: 12450074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This open-labeled single-blinded study was performed to evaluate the efficacy and tolerability of telmisartan in the treatment of mild to moderate essential hypertension. Each patient was assigned to take a placebo for 4 weeks followed by once daily-titrated telmisartan (40-80 mg) for 8 weeks. "Office BP" and "24-hour ambulatory BP" measurements (24-h ABPM) were recorded as scheduled. Thirty-one patients (10 males: 21 females) with a mean age of 48.1 years were enrolled. The final SBP/DBP reductions of 14.6 +/- 14.2/9.9 +/- 6.2 mm Hg were obtained. Full response defined as office DBP reduction of > or = 10 mm Hg from baseline and/or DBP < 90 mm Hg was achieved in 73.3 per cent of cases. Excluding 5 cases of white coat HT diagnosed by 24-h ABPM, full response rate (DBP reduction of > or = 10 mm Hg from baseline and/or < 85 mm Hg) was 76 per cent. Trough to peak ratio and smoothness index for SBP/DBP were highly acceptable (0.75/0.76 and 0.97/1.01, respectively). There were 4 cases of adverse events (2 cases of dizziness, 1 case of headache, and 1 case of acute myocardial infarction). |
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Authors:
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Peera Buranakitjaroen; Meta Phoojaroenchanachai; Surachai Saravich; Pantip Sangprasert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 85 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2002-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 968-77 Citation Subset: IM |
Affiliation:
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Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II* Angiotensin-Converting Enzyme Inhibitors / adverse effects, therapeutic use* Benzimidazoles / adverse effects, therapeutic use* Benzoates / adverse effects, therapeutic use* Female Humans Hypertension / drug therapy* Male Middle Aged Receptors, Angiotensin / antagonists & inhibitors* Single-Blind Method Thailand |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 144701-48-4/telmisartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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