Document Detail


The efficacy and safety of pravastatin, compared to and in combination with bile acid binding resins, in familial hypercholesterolaemia.
MedLine Citation:
PMID:  2119419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty patients with familial hypercholesterolaemia (FH) were treated with 40 mg pravastatin once daily. Pravastatin decreased serum total and low density lipoprotein cholesterol (LDL) after 8 weeks of treatment by 28% and 33%, respectively, while high density lipoprotein cholesterol increased by 8% and triglycerides decreased by 14%. In 30 patients LDL cholesterol had not decreased below 5.0 mmol l-1 after 8 weeks of treatment, and in these patients resins were added to pravastatin, resulting in an additional decrease in total and LDL cholesterol of 8% and 12%, respectively. A control group of 22 FH patients was treated with placebo for 10 weeks, after which time resins were added, and they induced a decrease in total and LDL-cholesterol of 17% and 22%, respectively. Our results over a 24-week treatment period indicate that 40 mg pravastatin is more effective than 3 packets of resins in lowering LDL cholesterol, whereas the combination is most effective of all and can be used safely.
Authors:
N Hoogerbrugge; M J Mol; J J Van Dormaal; C Rustemeijer; E Muls; A F Stalenhoef; J C Birkenhäger
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  228     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Affiliation:
University Hospital Dijkzigt, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Anticholesteremic Agents / adverse effects,  therapeutic use
Bile Acids and Salts / therapeutic use*
Carrier Proteins / therapeutic use*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Heptanoic Acids / adverse effects,  therapeutic use*
Humans
Hydroxysteroid Dehydrogenases*
Hyperlipoproteinemia Type II / drug therapy*
Male
Membrane Glycoproteins*
Naphthalenes / adverse effects,  therapeutic use*
Pravastatin
Randomized Controlled Trials as Topic
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Bile Acids and Salts; 0/Carrier Proteins; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Membrane Glycoproteins; 0/Naphthalenes; 0/Triglycerides; 0/bile acid binding proteins; 81093-37-0/Pravastatin; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC 1.1.1.-/AKR1C2 protein, human
Comments/Corrections
Comment In:
J Intern Med. 1990 Sep;228(3):201-5   [PMID:  2401870 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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