| The efficacy and safety of low-dose corticosteroids for rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 1948096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low-dose corticosteroids (defined as less than or equal to 10 mg/d of prednisone or equivalent) are used increasingly for the management of rheumatoid arthritis. They are frequently substituted for nonsteroidal antiinflammatory drugs (NSAIDs), particularly in patients with gastrointestinal or other intolerance to NSAIDs, or as "bridge therapy" while patients await the benefits of delayed-acting, disease-modifying agents. Despite their clinical acceptance, published data concerning efficacy are meager. Adverse effects to low-dose corticosteroids are not so frequent nor so severe as those that occur with higher doses. Nevertheless, alterations in glucose metabolism, cutaneous atrophy, cataracts, and glaucoma are common. Osteoporosis, steroid-myopathy, a steroid-withdrawal syndrome, and dysfunction of the hypothalamic-pituitary-adrenal axis appear in some patients. Osteonecrosis, gastrointestinal, cardiovascular, infectious, or neurological complications probably do not occur. Fetal wastage, prematurity, or congenital malformations have not been proven with this dosage. |
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Authors:
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J R Caldwell; D E Furst |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in arthritis and rheumatism Volume: 21 ISSN: 0049-0172 ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-12-04 Completed Date: 1991-12-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Halifax Clinical Research Center, Daytona Beach, FL 32114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage*,
adverse effects,
therapeutic use Arthritis, Rheumatoid / drug therapy* Bone Diseases / chemically induced Coronary Disease / chemically induced Diabetes Mellitus / chemically induced Eye Diseases / chemically induced Female Gastrointestinal Diseases / chemically induced Humans Hypothalamo-Hypophyseal System / drug effects Infection / etiology Muscles / drug effects Pituitary-Adrenal System / drug effects Pregnancy / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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