Document Detail

The efficacy and safety of low-dose corticosteroids for rheumatoid arthritis.
MedLine Citation:
PMID:  1948096     Owner:  NLM     Status:  MEDLINE    
Low-dose corticosteroids (defined as less than or equal to 10 mg/d of prednisone or equivalent) are used increasingly for the management of rheumatoid arthritis. They are frequently substituted for nonsteroidal antiinflammatory drugs (NSAIDs), particularly in patients with gastrointestinal or other intolerance to NSAIDs, or as "bridge therapy" while patients await the benefits of delayed-acting, disease-modifying agents. Despite their clinical acceptance, published data concerning efficacy are meager. Adverse effects to low-dose corticosteroids are not so frequent nor so severe as those that occur with higher doses. Nevertheless, alterations in glucose metabolism, cutaneous atrophy, cataracts, and glaucoma are common. Osteoporosis, steroid-myopathy, a steroid-withdrawal syndrome, and dysfunction of the hypothalamic-pituitary-adrenal axis appear in some patients. Osteonecrosis, gastrointestinal, cardiovascular, infectious, or neurological complications probably do not occur. Fetal wastage, prematurity, or congenital malformations have not been proven with this dosage.
J R Caldwell; D E Furst
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  21     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-04     Completed Date:  1991-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Halifax Clinical Research Center, Daytona Beach, FL 32114.
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage*,  adverse effects,  therapeutic use
Arthritis, Rheumatoid / drug therapy*
Bone Diseases / chemically induced
Coronary Disease / chemically induced
Diabetes Mellitus / chemically induced
Eye Diseases / chemically induced
Gastrointestinal Diseases / chemically induced
Hypothalamo-Hypophyseal System / drug effects
Infection / etiology
Muscles / drug effects
Pituitary-Adrenal System / drug effects
Pregnancy / drug effects
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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