| The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants. | |
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MedLine Citation:
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PMID: 17304425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to examine the efficacy and safety of early nonionic iron supplementation in preterm infants. Infants with gestational age < or = 32 weeks who were fed enriched human milk were assigned concurrently to receive 5 mg/kg/d enteral iron polymaltose complex (IPC) at 2 or 4 weeks of age. The levels of hemoglobin, reticulocytes, serum iron, ferritin, and soluble transferrin receptor were recorded at 2, 4, and 8 weeks of age. The incidence of morbidities associated with prematurity and the need for red blood cell transfusions (RBCTs) were recorded. The 2-week group (n = 32) had a better iron status than the 4-week group (n = 36) at 4 weeks and at 8 weeks of age. The incidence of morbidities associated with prematurity was not different among the groups ( P = 0.26). RBCT was required in one infants of the 2-week group and in 10 infants in the 4-week group ( P = 0.045). The number needed to treat to prevent one RBCT was five. Supplementation of 5 mg/kg/d enteral IPC to preterm infants fed enriched human milk as early as 2 weeks of age was more beneficial to iron status than at 4 weeks of age, and was associated with decreased need for RBCTs and no increase in the incidence of morbidities associated with prematurity. |
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Authors:
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Shmuel Arnon; Yakov Shiff; Ita Litmanovitz; Rivka H Regev; Sofia Bauer; Ruth Shainkin-Kestenbaum; Yoram Bental; Tzipora Dolfin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2007-02-15 |
Journal Detail:
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Title: American journal of perinatology Volume: 24 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-03-02 Completed Date: 2007-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Meir Medical Center, Kfar Saba, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dietary Supplements* Erythrocyte Transfusion Female Ferric Compounds / administration & dosage* Glycoproteins / administration & dosage* Humans Infant, Newborn Infant, Premature* Male Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 0/Glycoproteins; 0/polysaccharide-protein complex, Candida; 79173-09-4/teferrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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