Document Detail


The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants.
MedLine Citation:
PMID:  17304425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to examine the efficacy and safety of early nonionic iron supplementation in preterm infants. Infants with gestational age < or = 32 weeks who were fed enriched human milk were assigned concurrently to receive 5 mg/kg/d enteral iron polymaltose complex (IPC) at 2 or 4 weeks of age. The levels of hemoglobin, reticulocytes, serum iron, ferritin, and soluble transferrin receptor were recorded at 2, 4, and 8 weeks of age. The incidence of morbidities associated with prematurity and the need for red blood cell transfusions (RBCTs) were recorded. The 2-week group (n = 32) had a better iron status than the 4-week group (n = 36) at 4 weeks and at 8 weeks of age. The incidence of morbidities associated with prematurity was not different among the groups ( P = 0.26). RBCT was required in one infants of the 2-week group and in 10 infants in the 4-week group ( P = 0.045). The number needed to treat to prevent one RBCT was five. Supplementation of 5 mg/kg/d enteral IPC to preterm infants fed enriched human milk as early as 2 weeks of age was more beneficial to iron status than at 4 weeks of age, and was associated with decreased need for RBCTs and no increase in the incidence of morbidities associated with prematurity.
Authors:
Shmuel Arnon; Yakov Shiff; Ita Litmanovitz; Rivka H Regev; Sofia Bauer; Ruth Shainkin-Kestenbaum; Yoram Bental; Tzipora Dolfin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-02-15
Journal Detail:
Title:  American journal of perinatology     Volume:  24     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Meir Medical Center, Kfar Saba, Israel.
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MeSH Terms
Descriptor/Qualifier:
Dietary Supplements*
Erythrocyte Transfusion
Female
Ferric Compounds / administration & dosage*
Glycoproteins / administration & dosage*
Humans
Infant, Newborn
Infant, Premature*
Male
Prospective Studies
Chemical
Reg. No./Substance:
0/Ferric Compounds; 0/Glycoproteins; 0/polysaccharide-protein complex, Candida; 79173-09-4/teferrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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