Document Detail

The efficacy of rifampin as adjunctive therapy in selected cases of staphylococcal endocarditis.
MedLine Citation:
PMID:  630934     Owner:  NLM     Status:  MEDLINE    
Three patients with bacterial endocarditis (one case due to Staphylococcus aureus and two to S epidermidis) failed to improve on standard therapeutic regimens which were judged adequate by in vitro testing for sensitivity. Rifampin was added to the regimen in each case and resulted in increased bactericidal activity in the serum, sterilization of the cardiac valves, and clinical cure. The apparent clinical success that was achieved suggests that further investigation of the effectiveness of therapy with rifampin in selected cases of staphylococcal endocarditis is warranted.
R M Massanari; S T Donta
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  73     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  AIM; IM    
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MeSH Terms
Endocarditis, Bacterial / drug therapy*
Microbial Sensitivity Tests
Middle Aged
Oxacillin / therapeutic use
Rifampin / therapeutic use*
Staphylococcal Infections / drug therapy*
Vancomycin / therapeutic use
Reg. No./Substance:
13292-46-1/Rifampin; 1404-90-6/Vancomycin; 66-79-5/Oxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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